Glador M 2 Fort Tablet

Generic Composition:

• Glimepiride 2 mg (Sulfonylurea)

• Metformin Hydrochloride 1000 mg (Biguanide, Extended Release)

Category: Oral Anti-Diabetic (Dual Combination)

---

Description:

Glador M 2 Fort Tablet is an oral anti-diabetic combination medicine used to manage Type 2 Diabetes Mellitus in adults when diet, exercise, and single-drug therapy are not sufficient.

• Glimepiride lowers blood sugar by stimulating the pancreas to release more insulin.

• Metformin reduces glucose production in the liver, slows glucose absorption from the intestines, and improves the body’s response to insulin.

Together, they provide better glycemic control, lowering both fasting and postprandial (after-meal) blood sugar levels, and help prevent long-term complications of diabetes.

---

Uses:

• Treatment of Type 2 Diabetes Mellitus

• Helps reduce risk of complications like neuropathy, kidney damage, retinopathy, heart attack, and stroke

---

Mechanism of Action:

• Glimepiride (2 mg): Stimulates pancreatic beta cells → increases insulin secretion → lowers blood glucose

• Metformin (1000 mg ER): Reduces liver glucose output, delays intestinal glucose absorption, improves insulin sensitivity

• Combined effect: Strong glycemic control with lower risk of severe fluctuations

---

Dosage & Administration:

• Usually 1 tablet once daily with meals (doctor decides dose based on patient’s sugar levels)

• Must be taken with food to minimize gastrointestinal upset and risk of hypoglycemia

• Swallow whole with water; do not crush or chew (extended release)

• Regular monitoring of blood sugar and HbA1c is advised

---

Common Side Effects:

• Hypoglycemia (low blood sugar) – sweating, shakiness, dizziness, hunger

• Nausea, vomiting, diarrhea, stomach upset (Metformin-related)

• Headache, weakness

• Weight gain (possible with Glimepiride)

---

Serious Side Effects (rare):

• Lactic acidosis (Metformin): extreme fatigue, muscle pain, difficulty breathing

• Severe hypoglycemia (especially if skipping meals or strenuous exercise)

• Liver dysfunction – yellowing of skin/eyes, dark urine

• Allergic reactions – rash, swelling, breathing difficulty

---

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Avoid alcohol (increases risk of hypoglycemia & lactic acidosis)

• Use cautiously in elderly patients

• Regular monitoring of blood glucose, kidney, and liver function is essential.