Glycomet GP-1 Tablet

Generic Composition:

• Glimepiride 1 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

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Description:

Glycomet GP 1 Tablet is a dual drug combination used to treat Type 2 Diabetes Mellitus in adults when diet, exercise, and monotherapy are not sufficient.

• Glimepiride helps lower blood sugar by stimulating the pancreas to release insulin.

• Metformin reduces glucose production in the liver, slows sugar absorption from the intestines, and improves the body’s insulin sensitivity.

Together, they provide better control of blood sugar levels, target both fasting and post-meal glucose, and help reduce the risk of long-term complications like kidney damage, nerve problems, heart disease, and eye damage.

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Uses:

• Treatment of Type 2 Diabetes Mellitus

• Reduces fasting and postprandial blood sugar

• Helps prevent diabetes-related complications (neuropathy, nephropathy, retinopathy, heart disease, stroke)

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Mechanism of Action:

• Glimepiride (1 mg): Stimulates pancreatic beta cells → increases insulin secretion → lowers blood glucose

• Metformin (500 mg): Decreases hepatic glucose production, slows intestinal sugar absorption, and improves insulin sensitivity

• Combined effect: Comprehensive glycemic control

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Dosage & Administration:

• Usually 1 tablet once or twice daily with meals (as prescribed by doctor)

• Must be taken with food to reduce stomach upset and hypoglycemia risk

• Swallow whole with water; do not crush or chew

• Regular blood sugar and HbA1c monitoring is recommended

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Common Side Effects:

• Hypoglycemia (low blood sugar): sweating, hunger, dizziness, shakiness

• Nausea, diarrhea, stomach upset (Metformin-related)

• Headache, weakness, metallic taste

• Weight gain (possible with Glimepiride)

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Serious Side Effects (rare):

• Lactic acidosis (Metformin): severe fatigue, breathing difficulty, muscle pain

• Severe hypoglycemia (especially if skipping meals)

• Liver problems: yellow skin/eyes, dark urine

• Allergic reactions: rash, swelling, breathing difficulty

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Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in patients with severe kidney or liver disease

• Avoid alcohol (increases risk of lactic acidosis & hypoglycemia)

• Use cautiously in elderly and heart patients

• Regular monitoring of blood glucose, kidney, and liver function is essential