Glycomet GP 2 Tablet

Generic Composition:

• Glimepiride 2 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

---

Description:

Glycomet GP 2 Tablet is a dual-drug combination used in the treatment of Type 2 Diabetes Mellitus in adults, particularly when diet, exercise, and monotherapy are not enough to maintain blood sugar levels.

• Glimepiride stimulates the pancreas to release more insulin, lowering blood sugar.

• Metformin reduces glucose production in the liver, delays absorption of sugar from the intestines, and improves the body’s response to insulin.

Together, they help achieve better control of blood sugar levels, target both fasting and post-meal glucose, and reduce the risk of long-term diabetes complications.

---

Uses:

• Treatment of Type 2 Diabetes Mellitus

• Controls fasting and postprandial blood sugar levels

• Helps reduce the risk of complications like kidney damage, nerve problems, eye disease, stroke, and heart disease

---

Mechanism of Action:

• Glimepiride (2 mg): Increases insulin secretion from pancreatic beta cells → lowers blood glucose

• Metformin (500 mg): Lowers liver glucose output, slows sugar absorption in intestines, improves tissue insulin sensitivity

• Combined effect: Improves glycemic control by addressing insulin secretion, sensitivity, and glucose production

---

Dosage & Administration:

• Usually taken once or twice daily with meals (as prescribed by doctor)

• Must be taken with food to minimize stomach upset and risk of hypoglycemia

• Swallow whole with water; do not crush or chew

• Regular blood sugar monitoring is required

---

Common Side Effects:

• Hypoglycemia – sweating, shakiness, dizziness, hunger

• Nausea, vomiting, diarrhea, stomach discomfort (Metformin-related)

• Headache, weakness, metallic taste

• Possible weight gain (with Glimepiride)

---

Serious Side Effects (rare):

• Lactic acidosis (from Metformin): extreme weakness, muscle pain, breathing difficulty

• Severe hypoglycemia (risk higher with missed meals or heavy exercise)

• Liver dysfunction – yellowing of eyes/skin, dark urine

• Severe allergic reactions – rash, swelling, breathing difficulty

---

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Avoid alcohol (raises risk of lactic acidosis & hypoglycemia)

• Use cautiously in elderly and heart patients

• Regular monitoring of blood sugar, HbA1c, kidney, and liver function is essential