Glycomet Trio 1 Tablet

Generic Composition:

• Glimepiride 1 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

• Voglibose 0.2 mg (Alpha-glucosidase inhibitor)

Category: Oral Anti-Diabetic (Triple Combination)

---

Description:

Glycomet Trio 1 Tablet is a triple-drug combination used to manage Type 2 Diabetes Mellitus in adults when diet, exercise, and monotherapy or dual therapy do not provide adequate control.

• Glimepiride stimulates the pancreas to release more insulin, lowering blood sugar.

• Metformin reduces liver glucose production, slows glucose absorption from the intestines, and improves insulin sensitivity.

• Voglibose delays the digestion and absorption of carbohydrates in the intestine, thus preventing post-meal blood sugar spikes.

Together, these three agents provide comprehensive blood sugar control by targeting multiple mechanisms.

---

Uses:

• Treatment of Type 2 Diabetes Mellitus

• Controls fasting and postprandial glucose levels

• Helps reduce risk of diabetes-related complications like neuropathy, kidney disease, retinopathy, and heart disease

---

Mechanism of Action:

• Glimepiride (1 mg): Increases insulin secretion from pancreatic beta cells → lowers blood sugar

• Metformin (500 mg): Reduces hepatic glucose output, improves insulin sensitivity, slows intestinal glucose absorption

• Voglibose (0.2 mg): Inhibits alpha-glucosidase enzyme → slows carbohydrate digestion → lowers post-meal glucose surge

• Combined effect: Strong glycemic control across fasting and post-meal sugars

---

Dosage & Administration:

• Usually 1 tablet once or twice daily with meals (as prescribed by doctor)

• Take just before meals for maximum effect (due to Voglibose action)

• Swallow whole with water; do not crush or chew

• Regular monitoring of blood glucose and HbA1c is required

---

Common Side Effects:

• Hypoglycemia (low blood sugar) – sweating, dizziness, shakiness, hunger

• Nausea, diarrhea, stomach upset (Metformin-related)

• Flatulence, bloating, abdominal discomfort (Voglibose-related)

• Headache, weakness

---

Serious Side Effects (rare):

• Lactic acidosis (Metformin): muscle pain, fatigue, breathing difficulty

• Severe hypoglycemia (especially if skipping meals or during heavy exercise)

• Liver problems – yellowing of skin/eyes, dark urine

• Severe allergic reactions – rash, swelling, breathing difficulty

---

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Use cautiously in patients with gastrointestinal problems (due to Voglibose)

• Avoid alcohol (increases risk of lactic acidosis and hypoglycemia)

• Regular monitoring of blood sugar, kidney, and liver function is essential