Zoryl M 2 Tablet

Generic Composition:

• Glimepiride 2 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

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Description:

Zoryl M 2 Tablet is a combination anti-diabetic medicine used to treat Type 2 Diabetes Mellitus when diet, exercise, and single therapy are insufficient to control blood sugar levels.

• Glimepiride lowers blood sugar by stimulating the pancreas to release more insulin.

• Metformin reduces glucose production in the liver, delays sugar absorption in the intestines, and enhances insulin sensitivity.

Together, they provide better control of fasting and postprandial (after-meal) blood sugar levels and reduce the risk of long-term complications such as kidney damage, nerve issues, heart disease, and eye damage.

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Uses:

• Treatment of Type 2 Diabetes Mellitus

• Helps regulate both fasting and post-meal glucose

• Reduces risk of complications related to diabetes

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Mechanism of Action:

• Glimepiride (2 mg): Stimulates pancreatic beta cells → increases insulin secretion → lowers blood sugar

• Metformin (500 mg): Reduces hepatic glucose production, slows intestinal sugar absorption, improves insulin sensitivity

• Combined effect: Comprehensive glycemic control by targeting insulin release and resistance

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Dosage & Administration:

• Typically 1 tablet once or twice daily with meals (as prescribed by doctor)

• Must be taken with food to reduce gastric side effects and hypoglycemia risk

• Swallow whole with water; do not crush or chew

• Regular monitoring of blood glucose and HbA1c is recommended

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Common Side Effects:

• Hypoglycemia (sweating, dizziness, shakiness, hunger)

• Nausea, diarrhea, abdominal discomfort (Metformin-related)

• Headache, weakness

• Weight gain (possible with Glimepiride)

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Serious Side Effects (rare):

• Lactic acidosis (from Metformin): muscle pain, extreme fatigue, breathing difficulty

• Severe hypoglycemia (if meals skipped or excess exercise)

• Liver dysfunction – yellowing of skin/eyes, dark urine

• Severe allergic reactions – rash, swelling, difficulty breathing

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Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Avoid alcohol (increases risk of lactic acidosis & hypoglycemia)

• Use with caution in elderly patients and heart disease patients

• Regular monitoring of blood glucose, kidney, and liver function is essential