Metrogyl Injection

Brand Name

Metrogyl Injection

Generic Name

Metronidazole (Injection) – usually 500 mg/100 ml IV infusion

Main Category

• Antiprotozoal & Antianaerobic Agent
  (Nitroimidazole derivative – not a typical antibiotic)

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Uses / Indications

• Severe anaerobic bacterial infections (when oral therapy not possible)

  • Intra-abdominal infections (peritonitis, abscess)

  • Pelvic infections (endometritis, tubo-ovarian abscess, vaginal vault sepsis)

  • Skin & soft tissue, bone & joint anaerobic infections

  • Septicemia caused by anaerobes

  • CNS infections (meningitis, brain abscess)

• Protozoal infections (severe cases)

  • Amoebiasis (incl. liver abscess)

  • Giardiasis

  • Trichomoniasis

• Surgical prophylaxis

  • Prevention of anaerobic infections during colorectal, gynecological, and abdominal surgery

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Dosage (General Guidance)

(Strictly under physician’s supervision)

• Adults (IV): 500 mg infused over 20–60 minutes every 8 hours

• Maximum daily dose: 4 g

• Children: 7.5 mg/kg every 8 hrs (IV infusion)

• Duration depends on severity & clinical response

Route: Intravenous infusion (slow); rarely intramuscular in emergency

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Side Effects

• Nausea, vomiting, metallic taste

• Headache, dizziness

• Thrombophlebitis at injection site

• Dark-colored urine (harmless)

• Rare: Peripheral neuropathy, seizures, allergic reactions, leukopenia

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Precautions / Warnings

• Avoid alcohol during & 48 hrs after therapy (disulfiram-like reaction)

• Caution in liver & kidney impairment (dose adjustment may be needed)

• Avoid in first trimester of pregnancy unless essential

• Crosses placenta & enters breast milk → consult doctor if breastfeeding

• Monitor patients with neurological disorders (risk of neuropathy, seizures)

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Drug Interactions

• Alcohol (severe reaction)

• Warfarin (↑ anticoagulant effect)

• Lithium (↑ serum levels)

• Disulfiram (psychotic reactions)

• Phenytoin/Phenobarbital (↓ metronidazole effect)

• Cimetidine (↑ plasma levels)

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Packaging

• Metrogyl Injection 100 ml bottle (500 mg/100 ml) for IV infusion

• Single-dose vial/ampoule (varies by pack size)

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Manufacturer

J.B. Chemicals & Pharmaceuticals Ltd.
Neelam Centre, Hind Cycle Road, Worli, Mumbai, India