Cardace-H 5/12.5 Tablet

Basic Information

• Brand Name: Cardace-H 5/12.5 Tablet

• Generic Name: Ramipril + Hydrochlorothiazide

• Strength: Ramipril 5 mg + Hydrochlorothiazide 12.5 mg

• Category: Antihypertensive (ACE Inhibitor + Thiazide Diuretic)

• Manufacturer: Sanofi India Ltd.

• Prescription Required: Yes (Rx)

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Composition

Each tablet contains:

• Ramipril 5 mg (ACE Inhibitor)

• Hydrochlorothiazide 12.5 mg (Thiazide Diuretic – water pill)

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Uses / Indications

Cardace-H 5/12.5 Tablet is prescribed for:

• Hypertension (High Blood Pressure) – when single therapy is not sufficient.

• Reducing the long-term risk of stroke, heart attack, heart failure, and kidney complications.

• Patients with fluid retention (edema) due to diuretic effect.

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Mechanism of Action

• Ramipril (ACE Inhibitor): Prevents conversion of angiotensin I to angiotensin II → relaxes & widens blood vessels → lowers BP.

• Hydrochlorothiazide (Diuretic): Increases urine output → removes excess salt & water → lowers BP.

• Together, they provide dual action for stronger and sustained blood pressure control.

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Dosage & Administration

• Usual adult dose: 1 tablet once daily.

• Can be taken with or without food.

• Take at the same time each day.

• Do not discontinue suddenly without doctor’s advice.

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Side Effects

Common side effects:

• Dizziness, headache

• Increased urination

• Weakness, tiredness

• Dry cough (from Ramipril)

• Nausea, stomach upset

Serious but rare:

• Very low BP

• High potassium (from Ramipril) or low potassium (from HCTZ)

• Kidney impairment

• Angioedema (swelling of face/throat – medical emergency)

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Precautions & Warnings

• Use with caution in patients with:

  • Kidney or liver disease

  • Heart failure

  • Electrolyte imbalance (sodium/potassium disturbances)

• Not safe during pregnancy or breastfeeding.

• Avoid alcohol (may worsen dizziness).

• Regular monitoring of BP, kidney function, and electrolytes is required.

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Drug Interactions

• Other antihypertensives (additive effect)

• Potassium supplements / potassium-sparing diuretics

• NSAIDs (ibuprofen, diclofenac – may reduce effect & harm kidneys)

• Lithium (risk of toxicity)

• Antidiabetic medicines (HCTZ may affect blood sugar levels)

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Storage

• Store below 30°C in a dry, cool place.

• Protect from moisture & sunlight.

• Keep out of children’s reach.