Huminsulin 30/70 Injection

Generic Name: Biphasic Insulin (30% Regular Human Insulin + 70% NPH Insulin)
Category: Injectable Anti-Diabetic (Insulin Preparation)

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Description:

Huminsulin 30/70 is a premixed insulin injection used in the treatment of Diabetes Mellitus (Type 1 and Type 2). It contains 30% soluble (regular) insulin and 70% isophane (NPH) insulin.

• The regular insulin acts quickly to control blood sugar spikes after meals.

• The NPH insulin provides a longer-lasting effect to maintain baseline sugar control between meals and overnight.

This combination ensures both immediate and sustained control of blood sugar throughout the day.

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Uses:

• Management of Type 1 Diabetes Mellitus

• Management of Type 2 Diabetes Mellitus (when oral medicines are insufficient)

• Control of blood sugar during surgery, infection, or other critical illness when oral drugs are not suitable

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Mechanism of Action:

• Regular Insulin (30%): Rapid-acting, lowers blood glucose by promoting glucose uptake into cells and inhibiting liver glucose production

• NPH Insulin (70%): Intermediate-acting, maintains stable insulin levels for long-term control

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Dosage & Administration:

• Administered subcutaneously (under the skin) in areas such as the abdomen, thigh, or upper arm

• Dose is individualized by the doctor depending on blood sugar levels, diet, and physical activity

• Usually injected 15–30 minutes before meals

• Rotate injection sites regularly to avoid skin problems (lipodystrophy)

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Common Side Effects:

• Hypoglycemia (low blood sugar): sweating, hunger, dizziness, shakiness, confusion

• Injection site pain, redness, or swelling

• Weight gain

• Temporary vision changes at the start of therapy

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Serious Side Effects (rare):

• Severe hypoglycemia → seizures, unconsciousness (requires immediate medical care)

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Lipodystrophy (skin thickening/thinning at injection site)

• Low potassium levels (hypokalemia, rare)

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Warnings & Precautions:

• Not to be used during hypoglycemia episodes

• Caution in patients with kidney, liver, or heart disease

• Avoid alcohol (increases risk of low blood sugar)

• Regular monitoring of blood glucose, HbA1c, and electrolytes is required

• Always keep sugar/glucose source handy in case of low sugar attacks

• Store insulin in the refrigerator (2–8°C) but do not freeze