Istavel 100 mg Tablet

Generic Name: Sitagliptin Phosphate 100 mg
Category: Oral Anti-Diabetic (DPP-4 Inhibitor)

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Description:

Istavel 100 mg Tablet is an oral anti-diabetic medicine used to control Type 2 Diabetes Mellitus. It contains Sitagliptin, which belongs to the class of DPP-4 inhibitors (Dipeptidyl Peptidase-4 inhibitors).

It works by increasing incretin hormone levels, which stimulate the pancreas to release insulin in response to meals and reduce excess sugar production in the liver. This helps lower blood sugar levels effectively without causing significant weight gain.

Istavel can be used alone or in combination with other anti-diabetic medicines such as Metformin, Sulfonylureas, or Insulin.

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Uses:

• Type 2 Diabetes Mellitus

• Helps prevent complications of diabetes like kidney damage, blindness, nerve issues, heart disease, and stroke

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Mechanism of Action:

• Inhibits DPP-4 enzyme → increases incretin hormones

• Incretins boost insulin release after meals

• Reduce hepatic (liver) glucose production

• Improve overall glycemic control

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Dosage & Administration:

• Usual dose: 100 mg once daily, with or without food

• Dose adjustment required in patients with kidney disease

• Should be taken at the same time daily for best effect

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Common Side Effects:

• Headache

• Stomach pain, nausea, diarrhea, constipation

• Cold, sore throat, or upper respiratory infection

• Joint pain (rare but reported)

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Serious Side Effects (rare):

• Pancreatitis (severe abdominal pain, vomiting)

• Severe allergic reactions (rash, swelling of face/tongue, difficulty breathing)

• Worsening kidney function (rare)

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Warnings & Precautions:

• Not suitable for Type 1 Diabetes or diabetic ketoacidosis

• Use with caution in patients with kidney disease or pancreatitis

• Monitor blood sugar regularly

• Risk of hypoglycemia increases when combined with other anti-diabetic medicines (like sulfonylureas or insulin)

• Avoid excess alcohol consumption