Tazact 4.5 g Injection

Brand Name: Tazact 4.5 g Injection
Composition: Piperacillin 4 g + Tazobactam 0.5 g
Dosage Form: Injection (IV)
Manufacturer: Cipla Ltd.
Category: Broad-Spectrum Antibiotic (Penicillin + Beta-lactamase inhibitor)

Description: Tazact 4.5 g Injection is a combination of Piperacillin (extended-spectrum penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). It kills harmful bacteria and prevents resistance, making it highly effective in treating severe bacterial infections. It is administered intravenously under medical supervision.

Uses:

• Pneumonia (including hospital-acquired)

• Urinary tract infections (UTI)

• Intra-abdominal infections (peritonitis, sepsis)

• Skin & soft tissue infections

• Bone & joint infections

• Gynecological infections

• Septicemia and post-operative infections

Dosage & Administration:

• Adults: 4.5 g IV every 6–8 hours (depending on severity).

• Children: 100 mg/kg/day (Piperacillin component) in divided doses.

• Adjust dose in patients with renal impairment.
  👉 Dose strictly as per doctor’s advice.

Side Effects: Diarrhea, nausea, vomiting, rash, injection site reactions, headache, constipation. Rare: low blood counts, electrolyte imbalance, seizures (in very high doses).

Precautions:

• Avoid in patients allergic to penicillins, cephalosporins, or beta-lactam antibiotics.

• Use with caution in kidney disease and patients with history of seizures.

• Safe in pregnancy/lactation only if prescribed by doctor.

Drug Interactions:

• May interact with aminoglycosides (reduced effectiveness if mixed in same IV line).

• May increase risk of bleeding with anticoagulants (warfarin, heparin).

• Probenecid increases Piperacillin levels.

• May reduce efficacy of oral contraceptives.

• Inform doctor about all medicines before use.

Storage: Store below 25°C, protect from light & moisture. Reconstituted solution should be used immediately. Keep away from children.