Tenepla-M 20/500 Tablet

Generic Composition:

• Teneligliptin 20 mg (DPP-4 Inhibitor)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

---

Description:

Tenepla-M 20/500 Tablet is an oral anti-diabetic medicine used to manage Type 2 Diabetes Mellitus in adults when diet, exercise, and single therapy are insufficient to control blood sugar.

• Teneligliptin (DPP-4 inhibitor) works by increasing incretin hormones, which stimulate insulin secretion (only when blood sugar is high) and suppress glucagon release, thereby lowering blood glucose levels.

• Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves the body’s insulin sensitivity.

Together, they provide effective control of fasting and post-meal blood sugar levels and reduce the risk of long-term diabetes complications.

---

Uses:

• Management of Type 2 Diabetes Mellitus

• Helps lower fasting and postprandial glucose

• Reduces the risk of diabetes-related complications (kidney disease, nerve damage, heart disease, and eye problems)

---

Mechanism of Action:

• Teneligliptin (20 mg): Inhibits DPP-4 enzyme → prolongs incretin activity → increases insulin release & decreases glucagon → lowers blood sugar

• Metformin (500 mg): Reduces liver glucose output, slows intestinal glucose absorption, enhances insulin sensitivity

• Combined effect: Comprehensive glycemic control

---

Dosage & Administration:

• Typically 1 tablet once or twice daily with meals (as prescribed by doctor)

• Take with food to reduce gastric side effects (from Metformin)

• Swallow whole with water; do not crush or chew

• Regular monitoring of blood sugar and HbA1c is required

---

Common Side Effects:

• Nausea, diarrhea, stomach upset (Metformin-related)

• Headache, mild throat/respiratory infections (Teneligliptin-related)

• Hypoglycemia (low blood sugar – more likely with other anti-diabetics)

• Fatigue, dizziness, loss of appetite

---

Serious Side Effects (rare):

• Lactic acidosis (Metformin): muscle pain, tiredness, difficulty breathing

• Pancreatitis (rare with Teneligliptin): severe stomach pain, vomiting

• Liver problems: yellowing of skin/eyes, dark urine

• Allergic reactions: swelling, rash, breathing difficulty

---

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Avoid alcohol (increases lactic acidosis risk with Metformin)

• Use cautiously in elderly and heart patients

• Regular monitoring of blood glucose, kidney, and liver function is essential