Brand Name
Zifi-O 400
Generic Name / Composition
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Cefixime 200 mg (3rd Generation Cephalosporin Antibiotic)
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Ofloxacin 200 mg (Fluoroquinolone Antibiotic)
(Total strength per tablet: 400 mg)
Main Category
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Antibiotic Combination (Cephalosporin + Fluoroquinolone)
Description
Zifi-O 400 Tablet is a dual-action broad-spectrum antibiotic containing Cefixime + Ofloxacin.
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Cefixime stops bacterial growth by inhibiting cell wall synthesis.
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Ofloxacin kills bacteria by blocking DNA gyrase, preventing replication.
This combination provides strong coverage against resistant and mixed infections.
Uses / Indications
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Respiratory tract infections (tonsillitis, pharyngitis, bronchitis, pneumonia)
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ENT infections (sinusitis, otitis media)
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Urinary tract infections (UTI)
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Gastrointestinal infections (infective diarrhea, dysentery, typhoid fever)
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Skin & soft tissue infections
Dosage (General Guidance)
(As prescribed by physician)
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Adults: 1 tablet twice daily (Cefixime 200 mg + Ofloxacin 200 mg)
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Children: Not recommended; pediatric forms are preferred
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Duration: Typically 5–10 days depending on infection
Route: Oral
Advice: Take after meals with water to minimize gastric irritation
Side Effects
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Nausea, vomiting, stomach pain
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Diarrhea, loose stools
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Headache, dizziness
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Rash, itching (allergy)
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Rare: Tendonitis/tendon rupture (Ofloxacin-related), liver enzyme changes, severe allergic reactions
Precautions / Warnings
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Not effective in viral infections (cold, flu)
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Avoid if allergic to cephalosporins, penicillins, or fluoroquinolones
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Use cautiously in kidney/liver impairment, epilepsy, or tendon disorders
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Avoid in pregnancy & breastfeeding unless advised by doctor
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Complete the full antibiotic course to avoid resistance
Drug Interactions
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Antacids & iron supplements (↓ Ofloxacin absorption)
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Warfarin (↑ bleeding risk)
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Probenecid (↑ Cefixime concentration)
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Corticosteroids (↑ risk of tendon rupture with Ofloxacin)
Packaging
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Strip of 10 tablets
Manufacturer
FDC Limited
Mumbai, India
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