Coly-Mycin 1M Injection

Brand Name: Coly-Mycin 1M Injection
Composition: Colistimethate Sodium (Colistin) 1 Million IU
Dosage Form: Injection (IV/IM)
Manufacturer: Cipla Ltd.
Category: Polymyxin Antibiotic (Last-line for MDR infections)

Description: Coly-Mycin 1M Injection contains Colistimethate Sodium, also known as Colistin, an antibiotic reserved for multi-drug resistant Gram-negative infections. It works by damaging the bacterial cell membrane, leading to bacterial death. This medicine is used in critically ill patients under strict hospital supervision.

Uses:

• Pneumonia (especially ventilator-associated pneumonia)

• Bloodstream infections (septicemia)

• Urinary tract infections (UTI)

• Abdominal infections

• Bone & joint infections

• Infections caused by multidrug-resistant organisms like Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae

Dosage & Administration:

• Adults: Loading dose followed by maintenance (as per infection severity & kidney function).

• Children: Dose calculated by weight.

• Route: IV infusion or IM injection only.
  👉 Dose must be individualized and strictly given by doctor in hospital settings.

Side Effects: Kidney damage (nephrotoxicity), nerve toxicity (tingling, dizziness, muscle weakness), diarrhea, rash, injection site pain, breathing difficulty (rare).

Precautions:

• Avoid in patients allergic to Polymyxins.

• Use with extreme caution in kidney disease and neuromuscular disorders.

• Monitor kidney and nerve function during therapy.

• Use in pregnancy/lactation only if absolutely necessary.

Drug Interactions:

• Increased kidney toxicity with aminoglycosides, vancomycin, amphotericin B.

• May enhance neuromuscular blockade with muscle relaxants.

• Use cautiously with other nephrotoxic or neurotoxic drugs.

Storage: Store below 25°C, protect from moisture & light. Reconstituted solution should be used immediately or as per manufacturer’s guidelines. Keep away from children.