Gemer P1 Tablet

Generic Composition:

• Glimepiride 1 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

• Pioglitazone 15 mg (Thiazolidinedione)

Category: Oral Anti-Diabetic (Triple Combination)

Description:

Gemer P1 Tablet ER is a triple drug combination used for the management of Type 2 Diabetes Mellitus. It is prescribed when diet, exercise, and single/dual therapy are insufficient.

• Glimepiride stimulates the pancreas to release insulin, lowering blood sugar.

• Metformin reduces glucose production in the liver, delays intestinal sugar absorption, and improves insulin sensitivity.

• Pioglitazone enhances the body’s response to insulin in fat, muscle, and liver tissues.

Together, they provide powerful blood sugar control, reduce fluctuations in fasting and post-meal glucose, and help prevent diabetes-related complications.

Uses:

• Control of Type 2 Diabetes Mellitus in adults

• Reduces risk of long-term complications (kidney damage, neuropathy, retinopathy, heart disease, stroke)

Dosage & Administration:

• Taken once daily with food (as prescribed by doctor)

• Swallow whole; do not crush or chew (Extended Release formulation)

• Regular monitoring of blood sugar and HbA1c is necessary

Common Side Effects:

• Hypoglycemia (low blood sugar) – sweating, dizziness, hunger, tremors

• Stomach upset, diarrhea, nausea (Metformin-related)

• Weight gain, fluid retention (Pioglitazone-related)

• Headache, fatigue

Serious Side Effects (rare):

• Lactic acidosis (Metformin) – muscle pain, extreme tiredness, breathing difficulty

• Heart failure risk (Pioglitazone – use cautiously in heart patients)

• Liver problems – yellow skin/eyes, dark urine

• Severe allergic reactions

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney, liver, or heart disease

• Avoid alcohol (increases risk of hypoglycemia & lactic acidosis)

• Use cautiously in elderly patients

• Regular monitoring of blood glucose, kidney, and liver function is essential