Glimisave M1 Forte Tablet

Generic Composition:

• Glimepiride 1 mg (Sulfonylurea)

• Metformin Hydrochloride 1000 mg ER (Biguanide, Extended Release)

Category: Oral Anti-Diabetic (Dual Combination)

Description:

Glimisave M1 Forte Tablet is an oral anti-diabetic combination medicine used to treat Type 2 Diabetes Mellitus in adults when diet, exercise, and monotherapy are not sufficient.

• Glimepiride works by stimulating the pancreas to release more insulin, helping reduce blood sugar.

• Metformin (ER) reduces glucose production in the liver, decreases intestinal sugar absorption, and improves the body’s insulin sensitivity.

Together, they provide better control of blood sugar, reduce both fasting and post-meal sugar levels, and help lower the risk of long-term diabetes-related complications.

Uses:

• Management of Type 2 Diabetes Mellitus

• Helps prevent chronic complications such as neuropathy, nephropathy, retinopathy, heart attack, and stroke

Mechanism of Action:

• Glimepiride (1 mg): Stimulates insulin secretion from pancreatic beta cells → lowers blood sugar

• Metformin (1000 mg ER): Lowers hepatic glucose production, slows sugar absorption from intestines, improves insulin sensitivity

• Combined effect: Improved glycemic control with reduced sugar fluctuations

Dosage & Administration:

• Usually 1 tablet once daily with meals (as prescribed by doctor)

• Take with food to reduce stomach upset and risk of hypoglycemia

• Swallow whole with water; do not crush or chew (ER formulation)

• Regular monitoring of blood sugar and HbA1c is advised

Common Side Effects:

• Hypoglycemia – sweating, dizziness, hunger, shakiness

• Nausea, diarrhea, stomach upset (Metformin-related)

• Headache, weakness

• Weight gain (possible with Glimepiride)

Serious Side Effects (rare):

• Lactic acidosis (Metformin) – extreme tiredness, muscle pain, breathing difficulty

• Severe hypoglycemia (risk higher if meals are skipped)

• Liver dysfunction – yellow skin/eyes, dark urine

• Allergic reactions – rash, swelling, difficulty breathing

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in patients with severe kidney or liver disease

• Avoid alcohol (increases risk of lactic acidosis & hypoglycemia)

• Use cautiously in elderly patients

• Regular monitoring of blood glucose, kidney, and liver function is essential