Glimisave M2 Tablet

Generic Composition:

• Glimepiride 2 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

Description:

Glimisave M2 Tablet is a combination anti-diabetic medicine used to manage Type 2 Diabetes Mellitus in adults. It combines Glimepiride, which stimulates insulin release, and Metformin, which decreases liver glucose production, slows intestinal glucose absorption, and improves insulin sensitivity.

This dual therapy provides better blood sugar control, reduces both fasting and postprandial (after-meal) glucose levels, and helps lower the risk of long-term diabetes complications.

Uses:

• Management of Type 2 Diabetes Mellitus

• Helps prevent diabetes-related complications such as kidney damage, nerve problems, eye issues, heart disease, and stroke

Mechanism of Action:

• Glimepiride (2 mg): Stimulates pancreatic beta cells → increases insulin secretion → lowers blood glucose

• Metformin (500 mg): Reduces hepatic glucose production, slows intestinal absorption of glucose, improves tissue insulin sensitivity

• Combined effect: Effective control of both fasting and post-meal blood sugar levels

Dosage & Administration:

• Usually 1 tablet once or twice daily with meals (as prescribed by the doctor)

• Must be taken with food to minimize stomach upset and risk of hypoglycemia

• Swallow whole with water; do not crush or chew

• Regular monitoring of blood sugar and HbA1c is essential

Common Side Effects:

• Hypoglycemia – sweating, shakiness, dizziness, hunger

• Nausea, vomiting, diarrhea, stomach upset (Metformin-related)

• Headache, weakness

• Weight gain (possible with Glimepiride)

Serious Side Effects (rare):

• Lactic acidosis (Metformin): severe tiredness, muscle pain, difficulty breathing

• Severe hypoglycemia (more likely if meals are skipped or during heavy exercise)

• Liver dysfunction – yellow skin/eyes, dark urine

• Allergic reactions – rash, swelling, difficulty breathing

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Avoid alcohol (increases risk of hypoglycemia & lactic acidosis)

• Use cautiously in elderly patients

• Regular monitoring of blood sugar, kidney, and liver function is required