Invokana 100 mg Tablet

Generic Name: Canagliflozin 100 mg
Category: Oral Anti-Diabetic (SGLT2 Inhibitor)

Description:

Invokana 100 mg Tablet is an oral anti-diabetic medicine used to manage Type 2 Diabetes Mellitus. It contains Canagliflozin, which belongs to the SGLT2 inhibitor class (Sodium-Glucose Co-Transporter 2 inhibitors).

It works by blocking SGLT2 proteins in the kidneys, which are responsible for reabsorbing glucose back into the blood. By inhibiting these proteins, Invokana increases glucose excretion through urine, thereby lowering blood sugar levels.

Apart from diabetes control, Invokana also provides cardiovascular and kidney benefits, making it useful in patients with Type 2 Diabetes and associated heart or kidney disease.

Uses:

• Type 2 Diabetes Mellitus (to improve blood sugar control)

• Reduces risk of major cardiovascular events in adults with Type 2 diabetes and heart disease

• Helps slow progression of diabetic kidney disease

• May assist in weight reduction and blood pressure control

Mechanism of Action:

• Inhibits SGLT2 transporter in the kidneys

• Prevents glucose reabsorption into the bloodstream

• Promotes urinary glucose excretion (glycosuria)

• Reduces blood sugar levels, HbA1c, and body weight

• Provides cardio-renal protection

Dosage & Administration:

• Usual starting dose: 100 mg once daily, before the first meal of the day

• Can be increased to 300 mg daily if needed and tolerated (depending on kidney function)

• Adequate hydration should be maintained to prevent dehydration

• Doctor may adjust dose based on patient’s kidney function and overall condition

Common Side Effects:

• Increased urination

• Genital fungal infections (yeast infection, thrush)

• Urinary tract infections (UTI)

• Thirst, dehydration

• Low blood pressure (dizziness, fainting)

Serious Side Effects (rare):

• Diabetic Ketoacidosis (DKA) – nausea, vomiting, abdominal pain, confusion, rapid breathing

• Severe urinary tract infections (urosepsis, pyelonephritis)

• Fournier’s gangrene (rare but serious genital infection)

• Kidney problems (reduced kidney function)

• Increased risk of bone fractures and lower limb amputations (reported in some studies)

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Use with caution in patients with kidney disease, low blood pressure, or frequent UTIs

• Avoid excessive alcohol consumption (increases risk of ketoacidosis)

• Maintain proper genital hygiene to reduce infection risk

• Regular monitoring of blood sugar, kidney function, and electrolytes is essential