Metolar XR 25mg Tablet

Basic Information

• Brand Name: Metolar XR 25mg Tablet

• Generic Name: Metoprolol Succinate (Extended-Release)

• Strength: 25 mg

• Category: Antihypertensive / Beta-Blocker (Cardioselective)

• Manufacturer: Cipla Ltd.

• Prescription Required: Yes (Rx)

Composition

Each extended-release tablet contains:

• Metoprolol Succinate 25 mg (equivalent to Metoprolol Tartrate)

Uses / Indications

Metolar XR 25mg Tablet is prescribed for:

• Hypertension (High Blood Pressure)

• Angina (chest pain due to reduced oxygen supply to the heart)

• Arrhythmias (irregular heartbeat)

• Heart Failure (mild to moderate, with other medicines)

• Heart Attack (Myocardial Infarction) – reduces recurrence risk & improves survival

• Migraine prevention (off-label)

• Thyrotoxicosis symptoms (off-label)

Mechanism of Action

• Metoprolol is a Beta-1 Selective Blocker.

• Slows down the heart rate, reduces pumping force → lowers BP.

• Reduces oxygen demand of the heart → relieves angina.

• Stabilizes abnormal heart rhythms.

• XR (Extended-Release) formulation → provides 24-hour coverage with once-daily dose.

Dosage & Administration

• Usual adult dose: 25–200 mg once daily, depending on condition.

• 25 mg once daily is a common starting dose.

• Swallow whole with water; do not crush or chew (extended-release).

• Take with or just after meals.

• Do not discontinue suddenly – may cause rebound hypertension, angina, or arrhythmias.

Side Effects

Common side effects:

• Dizziness, tiredness

• Slow heartbeat (bradycardia)

• Cold hands/feet

• Nausea, stomach upset

• Sleep disturbance

Serious but rare:

• Severe low heart rate or BP

• Worsening of heart failure

• Breathing difficulty (rare, in asthma/COPD patients)

• Depression, mood changes

Precautions & Warnings

• Use with caution in patients with:

  • Heart block or severe bradycardia

  • Heart failure (unless monitored closely)

  • Asthma or COPD (though more selective, still caution needed)

  • Kidney or liver disease

• Not recommended in pregnancy or breastfeeding unless prescribed.

• Avoid alcohol (may worsen dizziness/drowsiness).

• Monitor BP and heart rate regularly.

Drug Interactions

• Other antihypertensives (extra BP lowering)

• Antiarrhythmics (digoxin, amiodarone – risk of slow HR)

• Insulin/antidiabetic drugs (masks hypoglycemia signs)

• NSAIDs (may reduce BP-lowering effect)

Storage

• Store below 30°C in a cool, dry place.

• Keep away from moisture & sunlight.

• Keep out of reach of children.