Metrogyl 200 Tablet

Brand Name

Metrogyl

Generic Name

Metronidazole 200 mg

Dosage Form

Film-coated oral tablet

Pharmacological Class

• Therapeutic Category: Antibacterial & Antiprotozoal

• Pharmacological Group: Nitroimidazole Derivative

• ATC Code: J01XD01

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Composition

Each tablet contains:

• Metronidazole 200 mg

• Excipients: Starch, lactose, povidone, magnesium stearate, talc & coloring agents

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Mechanism of Action

Metronidazole is reduced inside anaerobic bacteria & protozoa, producing toxic free radicals.
These radicals damage DNA structure, inhibit nucleic acid synthesis → cell death.

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Pharmacokinetics

• Absorption: Rapid, ~100% bioavailability

• Distribution: Wide (CNS, placenta, breast milk)

• Protein Binding: <20%

• Metabolism: Liver (oxidation & glucuronidation)

• Half-life: ~8 hrs

• Excretion: Mainly urine, some feces

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Indications / Uses

Protozoal Infections

• Amoebiasis (intestinal & hepatic)

• Giardiasis

• Trichomoniasis

Anaerobic Infections

• Intra-abdominal infections

• Pelvic infections

• Dental/orodental infections

• Septicemia, bone & joint infections

• Skin & soft tissue anaerobic infections

Other Uses

• Bacterial vaginosis

• Surgical prophylaxis (colorectal, gynecological, abdominal)

• H. pylori eradication (combination therapy)

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Dosage & Administration

(As per physician’s direction)

• Adults: 400–800 mg every 8–12 hrs

• Amoebiasis: 600–800 mg thrice daily for 5–10 days

• Trichomoniasis: 2 g single dose or divided regimen

• Children: 20–30 mg/kg/day in divided doses

Route: Oral
Advice: Take after meals to reduce gastric upset

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Adverse Effects

Common: Nausea, metallic taste, abdominal pain, headache
Uncommon: Dry mouth, dark urine, oral thrush
Serious: Peripheral neuropathy, seizures, blood dyscrasias, allergic reactions

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Contraindications

• Hypersensitivity to metronidazole/nitroimidazoles

• First trimester of pregnancy (unless essential)

• Alcohol consumption during & 48 hrs after therapy

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Precautions

• Avoid alcohol → severe disulfiram-like reaction

• Use cautiously in liver/kidney disease

• Monitor in neurological disorders

• Crosses placenta & milk → caution in pregnancy & breastfeeding

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Drug Interactions

• Alcohol (serious reaction)

• Warfarin (↑ bleeding risk)

• Disulfiram (psychotic reactions)

• Lithium (↑ toxicity)

• Phenytoin/Phenobarbital (↓ metronidazole effect)

• Cimetidine (↑ plasma levels)

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Overdose

• Symptoms: Seizures, ataxia, nausea, neuropathy

• Treatment: Supportive & symptomatic care. No specific antidote.

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Storage

• Store below 25°C, in a cool & dry place

• Protect from moisture & sunlight

• Keep out of children’s reach

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Packaging

• Blister strip of 10 tablets

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Manufacturer

J.B. Chemicals & Pharmaceuticals Ltd.
Neelam Centre, Hind Cycle Road, Worli, Mumbai, India