Metrogyl 600 Tablet

Brand Name

Metrogyl

Generic Name

Metronidazole 600 mg

Main Category

• Antiprotozoal & Antianaerobic Agent
  (Nitroimidazole derivative – not a typical antibiotic)

Uses / Indications

• Protozoal Infections

  • Intestinal & hepatic amoebiasis

  • Giardiasis

  • Trichomoniasis

• Anaerobic Bacterial Infections

  • Intra-abdominal infections (peritonitis, abscess)

  • Pelvic infections (endometritis, tubo-ovarian abscess, vaginal vault sepsis)

  • Dental/orodental infections (gingivitis, abscess, periodontitis)

  • Septicemia caused by anaerobes

  • Skin, soft tissue, bone & joint anaerobic infections

• Other Indications

  • Bacterial vaginosis

  • Surgical prophylaxis (colorectal, gynecological, abdominal surgery)

  • H. pylori eradication (in combination therapy)

Dosage (General Guidance)

(Strictly as directed by physician)

• Adults: 600–800 mg every 8–12 hrs depending on severity

• Amoebiasis: 800 mg TDS for 5–10 days

• Trichomoniasis: 2 g single dose or divided doses

• Children: 20–30 mg/kg/day in divided doses

Route: Oral
Advice: Take after meals to minimize gastric upset

Side Effects

• Nausea, vomiting, abdominal discomfort

• Metallic/bitter taste

• Headache, dizziness

• Dry mouth, dark-colored urine (harmless)

• Rare: Peripheral neuropathy, seizures, allergic reactions, leukopenia

Precautions / Warnings

• Alcohol: Avoid during treatment & 48 hrs after → severe disulfiram-like reaction

• Pregnancy: Avoid in 1st trimester unless essential

• Breastfeeding: Passes into milk – consult doctor before use

• Liver/Kidney Impairment: Dose adjustment may be required

• Neurological Disorders: Caution in patients with seizures/neuropathy

Drug Interactions

• Alcohol (dangerous reaction)

• Warfarin (↑ bleeding risk)

• Disulfiram (psychotic reactions)

• Lithium (↑ toxicity)

• Phenytoin/Phenobarbital (↓ metronidazole levels)

• Cimetidine (↑ plasma concentration)

Packaging

• Blister strip of 10 tablets

Manufacturer

J.B. Chemicals & Pharmaceuticals Ltd.
Neelam Centre, Hind Cycle Road, Worli, Mumbai, India