Nebistar 2.5mg Tablet

Basic Information

• Brand Name: Nebistar 2.5mg Tablet

• Generic Name: Nebivolol

• Strength: 2.5 mg

• Category: Antihypertensive / Beta-Blocker (Cardioselective with Vasodilating Action)

• Manufacturer: Lupin Ltd.

• Prescription Required: Yes (Rx)

Composition

Each tablet contains:

• Nebivolol 2.5 mg

Uses / Indications

Nebistar 2.5mg Tablet is prescribed for:

• Hypertension (High Blood Pressure)

• Chronic Heart Failure (mild to moderate, as add-on therapy)

• Angina (chest pain due to heart disease) – off-label use

• Arrhythmias (irregular heartbeat) – off-label use

Mechanism of Action

• Nebivolol is a highly selective Beta-1 Blocker with additional vasodilatory properties.

• It lowers heart rate and cardiac output → reduces blood pressure.

• It increases nitric oxide release in blood vessels → causes vasodilation (widening of blood vessels).

• This dual effect provides better blood pressure control with less risk of fatigue and cold extremities compared to older beta-blockers.

Dosage & Administration

• Usual adult dose: 2.5–5 mg once daily.

• 2.5 mg once daily is often the starting dose, especially in elderly or kidney-impaired patients.

• Can be taken with or without food.

• Take at the same time every day.

• Do not stop suddenly – may cause rebound hypertension or angina.

Side Effects

Common side effects:

• Headache, dizziness

• Fatigue, weakness

• Slow heartbeat (bradycardia)

• Stomach upset, nausea

• Insomnia or sleep disturbances

Serious but rare:

• Severe low heart rate or BP

• Shortness of breath (rare in sensitive patients)

• Worsening of heart failure

• Depression (uncommon)

Precautions & Warnings

• Use cautiously in patients with:

  • Heart block or severe bradycardia

  • Heart failure (unless closely monitored)

  • Kidney or liver disease

  • Asthma/COPD (safer than non-selective beta-blockers but still caution needed)

• Not recommended during pregnancy or breastfeeding unless prescribed.

• Avoid alcohol (may worsen dizziness).

• Regular monitoring of BP and heart rate is important.

Drug Interactions

• Other antihypertensives (extra BP lowering)

• Antiarrhythmics (digoxin, amiodarone – risk of bradycardia)

• Insulin/antidiabetic medicines (may mask low blood sugar symptoms)

• NSAIDs (may reduce BP-lowering effect)

Storage

• Store below 30°C in a cool, dry place.

• Protect from sunlight & moisture.

• Keep out of children’s reach.