Nebistar 5mg Tablet

Basic Information

• Brand Name: Nebistar 5mg Tablet

• Generic Name: Nebivolol

• Strength: 5 mg

• Category: Antihypertensive / Beta-Blocker (Cardioselective with Vasodilating Action)

• Manufacturer: Lupin Ltd.

• Prescription Required: Yes (Rx)

Composition

Each tablet contains:

• Nebivolol 5 mg

Uses / Indications

Nebistar 5mg Tablet is prescribed for:

• Hypertension (High Blood Pressure)

• Chronic Heart Failure (mild to moderate, as part of combination therapy)

• Angina (chest pain due to heart disease) – off-label use

• Arrhythmias (irregular heartbeat) – off-label use

Mechanism of Action

• Nebivolol is a highly selective Beta-1 Blocker with added vasodilating effect.

• Slows heart rate & reduces cardiac workload → lowers BP.

• Stimulates nitric oxide (NO) release in blood vessels → improves vasodilation & circulation.

• Provides effective BP control with fewer side effects (like cold hands/feet or fatigue) compared to older beta-blockers.

Dosage & Administration

• Usual adult dose: 5 mg once daily.

• Can be taken with or without food.

• Take at the same time every day.

• Do not discontinue suddenly – may cause rebound hypertension, chest pain, or arrhythmias.

Side Effects

Common side effects:

• Headache, dizziness

• Tiredness, weakness

• Slow heartbeat (bradycardia)

• Stomach upset, nausea

• Sleep disturbance (rare)

Serious but rare:

• Very low BP or heart rate

• Breathing difficulty (rare, more in asthma/COPD patients)

• Worsening of heart failure

• Severe allergic reaction (rash, swelling, difficulty breathing)

Precautions & Warnings

• Use with caution in patients with:

  • Severe heart block or bradycardia

  • Heart failure (unless closely monitored)

  • Kidney or liver impairment

  • Asthma/COPD (though safer, still caution needed)

• Not recommended during pregnancy or breastfeeding unless prescribed.

• Avoid alcohol (can increase dizziness or drowsiness).

• Regular monitoring of BP and heart rate is advised.

Drug Interactions

• Other antihypertensive medicines (enhanced effect)

• Antiarrhythmics (digoxin, amiodarone – risk of slow heartbeat)

• Insulin/antidiabetic medicines (may mask low sugar symptoms)

• NSAIDs (may reduce BP-lowering effect)

Storage

• Store below 30°C in a cool, dry place.

• Protect from sunlight & moisture.

• Keep away from children.