Pari CR 100 Tablet

Basic Information

• Brand Name: Pari CR 100 Tablet

• Type: Antidepressant / Anti-Anxiety (SSRI – Selective Serotonin Reuptake Inhibitor)

• Form: Controlled Release (CR) Tablet

• Pack Size: Strip of 10 tablets (commonly available in higher psychiatric prescriptions)

• Manufacturer / Marketer: Ipca Laboratories Ltd.

Composition (per tablet)

• Paroxetine Hydrochloride – 100 mg (Controlled Release)

Uses / Indications

Pari CR 100 Tablet is prescribed for severe and resistant psychiatric conditions, such as:

• Major Depressive Disorder (MDD)

• Generalized Anxiety Disorder (GAD)

• Obsessive-Compulsive Disorder (OCD)

• Severe Panic Disorder

• Social Anxiety Disorder (Social Phobia)

• Post-Traumatic Stress Disorder (PTSD)

• Premenstrual Dysphoric Disorder (PMDD)

• Treatment-resistant depression & OCD (when lower doses are not effective)

Mechanism of Action

• Paroxetine (SSRI):

  • Increases serotonin levels in the brain by blocking its reuptake

  • Helps regulate mood, reduce anxiety, control obsessive thoughts, and prevent panic attacks

• CR (Controlled Release): Ensures slow & sustained drug release, providing stable therapeutic effect and minimizing side effects

Dosage & Administration

• Adults: Typically 100 mg once daily, as prescribed by psychiatrist

• Take in the morning with food

• Swallow whole – do not crush or chew (to maintain CR effect)

• Discontinuation must be gradual → taper under medical supervision to avoid withdrawal effects

Side Effects

• Common: nausea, dizziness, drowsiness, constipation, dry mouth, sweating, headache

• Sexual side effects: decreased libido, delayed ejaculation, difficulty in orgasm

• Rare: tremors, blurred vision, weight changes, restlessness

• Severe (rare): suicidal thoughts (especially in early phase), serotonin syndrome

Precautions & Warnings

• Use strictly under psychiatrist’s supervision

• Do not stop suddenly → taper dose gradually

• Caution in patients with seizure history, bipolar disorder, severe liver/kidney disease

• Avoid alcohol (enhances sedation & side effects)

• Drug interactions: MAO inhibitors, anticoagulants, antipsychotics, other SSRIs/SNRIs

• Pregnant & breastfeeding women: use only if strongly indicated