Pari CR 12.5 Tablet

Basic Information

• Brand Name: Pari CR 12.5 Tablet

• Type: Antidepressant / Anti-anxiety Medicine (SSRI – Selective Serotonin Reuptake Inhibitor)

• Form: Controlled Release (CR) Tablet

• Pack Size: Strip of 10 tablets (commonly available)

• Manufacturer / Marketer: Ipca Laboratories Ltd.

Composition (per tablet)

• Paroxetine Hydrochloride – 12.5 mg (Controlled Release)

Uses / Indications

Pari CR 12.5 Tablet is prescribed in psychiatry & neurology for:

• Depression (Major Depressive Disorder)

• Anxiety disorders (Generalized Anxiety Disorder, Panic Disorder, Social Anxiety)

• Obsessive-Compulsive Disorder (OCD)

• Post-Traumatic Stress Disorder (PTSD)

• Premenstrual Dysphoric Disorder (PMDD)

• Panic attacks & associated phobias

Mechanism of Action

• Paroxetine (SSRI):

  • Increases serotonin levels in the brain by blocking its reuptake

  • Helps improve mood, reduce anxiety, and control obsessive thoughts

• CR (Controlled Release): Provides a slow & steady release → fewer side effects, better compliance

Dosage & Administration

• Adults: Usually 12.5–25 mg once daily, or as prescribed by psychiatrist

• Take once daily, preferably in the morning with food

• Swallow whole – do not crush or chew (as it is controlled release)

• Dosage is gradually adjusted based on patient’s response

Side Effects

• Common: nausea, headache, drowsiness, dizziness, dry mouth, constipation, sweating

• Sexual side effects: decreased libido, delayed ejaculation, difficulty in orgasm

• Rare: weight gain, tremors, blurred vision

• Very rare: suicidal thoughts (especially in young adults, initial phase)

Precautions & Warnings

• Use strictly under psychiatrist/doctor’s supervision

• Not to be stopped suddenly → taper gradually (to avoid withdrawal symptoms like irritability, dizziness, flu-like symptoms)

• Caution in patients with liver/kidney problems, seizures, glaucoma, or bipolar disorder

• Avoid alcohol (increases drowsiness & risk of side effects)

• Pregnant & breastfeeding women: use only if clearly prescribed

• May interact with MAO inhibitors, anticoagulants, antipsychotics, and other antidepressants