Pari CR 37.5 Tablet

Basic Information

• Brand Name: Pari CR 37.5 Tablet

• Type: Antidepressant / Anti-Anxiety (SSRI – Selective Serotonin Reuptake Inhibitor)

• Form: Controlled Release (CR) Tablet

• Pack Size: Strip of 10 tablets (commonly available)

• Manufacturer / Marketer: Ipca Laboratories Ltd.

Composition (per tablet)

• Paroxetine Hydrochloride – 37.5 mg (Controlled Release)

Uses / Indications

Pari CR 37.5 Tablet is prescribed in psychiatry for the treatment of:

• Major Depressive Disorder (MDD)

• Generalized Anxiety Disorder (GAD)

• Obsessive-Compulsive Disorder (OCD)

• Panic Disorder & Social Anxiety Disorder (Social Phobia)

• Post-Traumatic Stress Disorder (PTSD)

• Premenstrual Dysphoric Disorder (PMDD)

Mechanism of Action

• Paroxetine (SSRI):

  • Increases serotonin levels in the brain by blocking its reuptake

  • Improves mood, reduces anxiety, helps control obsessive thoughts & panic attacks

• CR (Controlled Release): Releases medicine gradually → ensures once-daily dosing with better tolerability

Dosage & Administration

• Adults: Typically 37.5 mg once daily, as prescribed by psychiatrist

• Take preferably in the morning with food

• Swallow whole – do not crush or chew (to maintain controlled release)

• Stopping should be gradual → tapering required (to avoid withdrawal symptoms)

Side Effects

• Common: nausea, headache, dizziness, drowsiness, sweating, constipation, dry mouth

• Sexual side effects: reduced libido, delayed ejaculation, difficulty in orgasm

• Rare: weight gain, tremors, blurred vision, agitation

• Severe (rare): suicidal thoughts (especially in young adults during early treatment)

Precautions & Warnings

• Use strictly under psychiatrist’s prescription

• Avoid abrupt discontinuation – taper slowly

• Caution in patients with bipolar disorder, seizures, severe liver/kidney disease

• Avoid alcohol (increases sedation & side effects)

• Drug interactions: MAO inhibitors, anticoagulants, other antidepressants, antipsychotics

• Pregnancy & breastfeeding: use only if clearly prescribed