Repace-H 50/12.5 Tablet

Basic Information

• Brand Name: Repace-H 50/12.5 Tablet

• Generic Name: Losartan + Hydrochlorothiazide

• Strength: Losartan 50 mg + Hydrochlorothiazide 12.5 mg

• Category: Antihypertensive (ARB + Thiazide Diuretic)

• Manufacturer: Sun Pharmaceutical Industries Ltd.

• Prescription Required: Yes (Rx)

Composition

Each tablet contains:

• Losartan Potassium 50 mg (Angiotensin II Receptor Blocker – ARB)

• Hydrochlorothiazide 12.5 mg (Thiazide Diuretic – water pill)

Uses / Indications

Repace-H 50/12.5 Tablet is prescribed for:

• Hypertension (High Blood Pressure) – especially when BP is not controlled by single medicine.

• Reduces long-term risk of stroke, heart attack, and kidney damage.

• Useful in patients with fluid retention (edema) due to the diuretic effect.

Mechanism of Action

• Losartan (ARB): Blocks angiotensin II → prevents narrowing of blood vessels → lowers BP.

• Hydrochlorothiazide (Diuretic): Increases urine output → removes extra salt & water → lowers BP.

• Together, they provide dual action for stronger and longer BP control.

Dosage & Administration

• Usual adult dose: 1 tablet once daily.

• Should be taken at the same time each day.

• Can be taken with or without food.

• Do not stop suddenly without doctor’s advice.

Side Effects

Common side effects:

• Dizziness, headache

• Increased urination

• Weakness, tiredness

• Stomach upset

Serious but rare:

• Very low blood pressure

• High potassium (from Losartan) or low potassium (from HCTZ)

• Kidney function impairment

• Severe allergic reaction (rash, swelling, breathing difficulty)

Precautions & Warnings

• Use with caution in patients with:

  • Kidney or liver disease

  • Heart failure

  • Electrolyte imbalance (low sodium, high/low potassium)

• Not safe during pregnancy or breastfeeding.

• Avoid alcohol (may increase dizziness).

• Regular monitoring of BP, kidney function, and electrolytes is advised.

Drug Interactions

• Other antihypertensive drugs (additive effect)

• Potassium supplements / potassium-sparing diuretics

• NSAIDs (ibuprofen, diclofenac – may reduce effect & harm kidneys)

• Lithium (risk of toxicity)

• Antidiabetic medicines (HCTZ may affect blood sugar control)

Storage

• Store below 30°C in a dry place.

• Protect from sunlight & moisture.

• Keep out of reach of children.