Volix-M 0.3/500 mg Tablet

Generic Name: Voglibose 0.3 mg + Metformin Hydrochloride 500 mg
Category: Oral Anti-Diabetic (Alpha-Glucosidase Inhibitor + Biguanide Combination)

Description:

Volix-M 0.3/500 mg Tablet is a combination medicine used to treat Type 2 Diabetes Mellitus. It contains Voglibose (an alpha-glucosidase inhibitor) and Metformin (a biguanide).

• Voglibose (0.3 mg): Slows down the digestion and absorption of carbohydrates in the intestine, preventing a rapid rise in blood sugar after meals (postprandial hyperglycemia).

• Metformin (500 mg): Reduces glucose production in the liver, decreases intestinal glucose absorption, and improves insulin sensitivity.

Together, they provide better overall glycemic control, especially for patients who struggle with post-meal sugar spikes.

Uses:

• Management of Type 2 Diabetes Mellitus

• Helps reduce post-meal blood sugar fluctuations

• Prevents long-term complications such as kidney damage, nerve issues, eye damage, heart disease, and stroke

Mechanism of Action:

• Voglibose: Inhibits alpha-glucosidase enzyme → delays carbohydrate breakdown → prevents sudden blood sugar rise after meals

• Metformin: Lowers hepatic glucose output, increases insulin sensitivity, slows intestinal glucose absorption

• Combined effect: Controls both fasting and post-meal blood sugar levels effectively

Dosage & Administration:

• Usually taken 1 tablet twice daily just before meals (doctor decides exact dose)

• Must be taken with food to maximize benefit and reduce side effects

• Swallow whole with water; do not crush or chew

• Dose adjustments may be needed in patients with kidney or liver problems

Common Side Effects:

• Flatulence (gas), bloating, abdominal discomfort (Voglibose-related)

• Nausea, diarrhea, stomach upset (Metformin-related)

• Headache, loss of appetite

• Hypoglycemia (low sugar, more likely if combined with insulin/sulfonylureas)

Serious Side Effects (rare):

• Lactic acidosis (from Metformin) – muscle pain, fatigue, difficulty breathing, confusion

• Severe gastrointestinal upset

• Liver dysfunction (rare)

• Allergic reactions (rash, swelling, difficulty breathing)

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver disease

• Use cautiously in patients with chronic gastrointestinal disorders

• Avoid alcohol (increases risk of lactic acidosis)

• Regular monitoring of blood glucose, HbA1c, kidney, and liver function is essential