Zoryl M 1 Tablet

Generic Composition:

• Glimepiride 1 mg (Sulfonylurea)

• Metformin Hydrochloride 500 mg (Biguanide)

Category: Oral Anti-Diabetic (Dual Combination)

Description:

Zoryl M 1 Tablet is a combination anti-diabetic medicine used in the treatment of Type 2 Diabetes Mellitus when diet, exercise, and monotherapy are not enough to control blood sugar.

• Glimepiride stimulates the pancreas to release insulin, thereby lowering blood sugar.

• Metformin reduces glucose production in the liver, delays glucose absorption from the intestine, and improves the body’s insulin sensitivity.

Together, they provide effective control of fasting and post-meal glucose levels and help reduce the risk of long-term diabetes complications like kidney damage, nerve problems, eye disease, heart disease, and stroke.

Uses:

• Treatment of Type 2 Diabetes Mellitus

• Controls both fasting and postprandial (after-meal) glucose

• Helps prevent long-term complications associated with diabetes

Mechanism of Action:

• Glimepiride (1 mg): Stimulates insulin release from pancreatic beta cells → lowers blood sugar

• Metformin (500 mg): Reduces hepatic glucose production, slows intestinal absorption of glucose, improves insulin sensitivity

• Combined effect: Comprehensive glycemic control with improved insulin action and secretion

Dosage & Administration:

• Typically 1 tablet once or twice daily with meals (as prescribed by doctor)

• Must be taken with food to minimize gastric upset and reduce risk of hypoglycemia

• Swallow whole with water; do not crush or chew

• Regular monitoring of blood sugar and HbA1c is advised

Common Side Effects:

• Hypoglycemia (low blood sugar): sweating, dizziness, shakiness, hunger

• Nausea, vomiting, diarrhea, stomach upset (Metformin-related)

• Headache, weakness

• Weight gain (possible with Glimepiride)

Serious Side Effects (rare):

• Lactic acidosis (Metformin): muscle pain, fatigue, difficulty breathing

• Severe hypoglycemia (especially if meals are skipped)

• Liver dysfunction – yellowing of skin/eyes, dark urine

• Allergic reactions: rash, swelling, breathing difficulty

Warnings & Precautions:

• Not for Type 1 Diabetes or diabetic ketoacidosis

• Avoid in severe kidney or liver impairment

• Avoid alcohol (increases risk of lactic acidosis & hypoglycemia)

• Use cautiously in elderly patients

• Regular monitoring of blood sugar, kidney, and liver function is necessary