Tenepride M Tablet

Basic Information

• Brand Name: Tenepride M Tablet

• Type: Antidiabetic Combination

• Form: Tablet

• Common Pack Size: Strip of 10 / 15 tablets

• Manufacturer / Marketer: Micro Labs Ltd.

Composition (per tablet)

• Teneligliptin – 20 mg

• Metformin Hydrochloride – 500 mg
  (also available in other strengths such as SR/PR forms)

Uses / Indications

Tenepride M Tablet is used in the management of Type 2 Diabetes Mellitus, particularly when:

• Diet and exercise alone do not provide adequate blood sugar control

• Monotherapy with metformin or teneligliptin is insufficient

• As part of combination therapy with other antidiabetic agents (if prescribed)

Mechanism of Action

• Metformin (Biguanide):

  • Decreases glucose production in the liver

  • Reduces intestinal absorption of glucose

  • Improves insulin sensitivity and peripheral glucose uptake

• Teneligliptin (DPP-4 inhibitor):

  • Inhibits DPP-4 enzyme, prolonging action of incretin hormones (GLP-1, GIP)

  • Increases insulin secretion & decreases glucagon release in a glucose-dependent manner

• Combined Effect: Provides effective control of both fasting and postprandial blood sugar levels

Dosage & Administration

• Usual Adult Dose: 1 tablet once daily (or as prescribed by physician)

• To be taken with meals to minimize gastric side effects

• Swallow whole with water – do not crush or chew

• Dose adjustments may be needed depending on blood glucose monitoring, kidney function, and other medications

Side Effects

• Common: nausea, diarrhea, abdominal discomfort, headache, mild hypoglycemia (especially if combined with other agents)

• Rare: skin rash, dizziness, taste disturbances

• Serious (rare):

  • Lactic acidosis (risk with metformin, especially in kidney impairment, alcohol use, or heart failure)

  • Pancreatitis (rare with DPP-4 inhibitors)

Precautions & Warnings

• Use strictly under doctor’s prescription

• Avoid in patients with severe kidney or liver disease, heart failure, or history of lactic acidosis

• Not for use in Type 1 diabetes or diabetic ketoacidosis

• Regular monitoring of blood sugar, HbA1c, and kidney function is recommended

• Caution with alcohol (increases lactic acidosis risk)

• Pregnant & breastfeeding women: use only if clearly prescribed by doctor

MRP (Approx.)